Orlistat online is a highly lipophilic hydrogenated derivative of lipostatin, a natural product from Streptomyces toxytricini;
Xenical 60 mg was approved by the FDA for OTC use in the US in February 2007. It is indicated for overweight adults who are >= 18 years of age.

Pharmacodynamics and pharmacokinetics

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Buy Xenical (Orlistat) Online
Xenical online is a reversible lipase inhibitor that acts locally in the stomach and small intestine. It is unlike any other available weight-loss medication
This unique mode of action is of particular benefit to consumers since orlistat does not act in
the central nervous system (CNS) and is not addictive
Xenical is minimally absorbed systemically (< 2%), and does not accumulate following
long term administration
Based on studies with orlistat 120 mg, 97% of orlistat is excreted in the faeces (83% unchanged), with complete elimination within 3–5 days. Plasma concentrations were minimal even when doses of up to 800 mg were administered (single-dose). This finding was also supported in multiple-dose studies in which patients received up to 400 mg 3 times a day.
Xenical online has a limited dose-response effect. Studies in healthy volunteers have shown that the maximum amount of fat excreted in the faeces following a 400 mg/day dose to be 32% of the dietary fat intake. Doses > 400 mg/day had no additional effect
Xenical 60 mg inhibits absorption of ~ 25% of ingested fats, compared with ~ 30% for orlistat 120 mg. Hence, orlistat 60 mg has ~ 85% the efficacy of the 120 mg dose
Orlistat has a short plasma half-life of 1–2h. It is metabolised in the intestinal wall to yield two pharmacologically inactive metabolites
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OBESITY IS

a chronic medical disorder affecting roughly one third of the population of the United States and is associated with increased morbidity and mortality. Considerable evidence suggests that weight loss of 5% to 10% of initial body weight substantially improves the health of obese patients. Diet and exercise, the cornerstones of obesity treatment, have limited effectiveness with respect to longterm weight loss and maintenance. Several studies suggest that adjunctive pharmacotherapy in combination with medical nutritional therapy improves long-term efficacy; however, some of these medications, now withdrawn, have been associated with serious adverse effects. Nonetheless, there is evidence that one of the most significant benefits of adjunctive pharmacotherapy for obesity lies in the long-term maintenance of weight loss. Obesity is one of the most common chronic conditions seen by primary care physicians; these physicians treat most obesity in the United States. However, poor long-term success in weight management, time constraints, and the absence of safe and effective drug therapy13,14 prevent primary care physicians from being even more involved in managing obesity. In addition, no studies to date have evaluated pharmacological treatment in primary care settings of individuals who are obese. The present study was undertaken to fill this gap in current knowledge. Xenical online is a selective and potent inhibitor of gastrointestinal (GI) lipases involved in triglyceride hydrolysis, which restricts the absorption of triglycerides from the GI tract. It has a low systemic absorption. A drug that alters the absorption of ingested nutrients can potentially induce negative energy balance, assuming incomplete dietary compensation. Buy Xenical reduces dietary fat absorption in a dose-dependent fashion, with a maximal inhibition of 30% fat absorption at a dosage of 120 mg 3 times a day (TID). Short-term, placebo-controlled studies have demonstrated that xenical produces greater weight loss than diet alone and is well tolerated in obese patients. The efficacy of buy xenical has been further established in a 2-year placebocontrolled trial that combined xenical with lifestyle intervention by physicans who specialize in treating obesity, and in a 1-year placebo-controlled study of patients with type 2 diabetes treated with oral sulfonylurea medications. The present study evaluated the efficacy of xenical online in producing and maintaining long-term weight loss, and in improving obesity-related risk factors in individuals who are obese and who received limited dietary and behavioral counseling in a primary care setting.
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