a chronic medical disorder affecting roughly one third of the population of the United States and is associated with increased morbidity and mortality. Considerable evidence suggests that weight loss of 5% to 10% of initial body weight substantially improves the health of obese patients. Diet and exercise, the cornerstones of obesity treatment, have limited effectiveness with respect to longterm weight loss and maintenance. Several studies suggest that adjunctive pharmacotherapy in combination with medical nutritional therapy improves long-term efficacy; however, some of these medications, now withdrawn, have been associated with serious adverse effects. Nonetheless, there is evidence that one of the most significant benefits of adjunctive pharmacotherapy for obesity lies in the long-term maintenance of weight loss. Obesity is one of the most common chronic conditions seen by primary care physicians; these physicians treat most obesity in the United States. However, poor long-term success in weight management, time constraints, and the absence of safe and effective drug therapy13,14 prevent primary care physicians from being even more involved in managing obesity. In addition, no studies to date have evaluated pharmacological treatment in primary care settings of individuals who are obese. The present study was undertaken to fill this gap in current knowledge. Xenical online is a selective and potent inhibitor of gastrointestinal (GI) lipases involved in triglyceride hydrolysis, which restricts the absorption of triglycerides from the GI tract. It has a low systemic absorption. A drug that alters the absorption of ingested nutrients can potentially induce negative energy balance, assuming incomplete dietary compensation. Buy Xenical reduces dietary fat absorption in a dose-dependent fashion, with a maximal inhibition of 30% fat absorption at a dosage of 120 mg 3 times a day (TID). Short-term, placebo-controlled studies have demonstrated that xenical produces greater weight loss than diet alone and is well tolerated in obese patients. The efficacy of buy xenical has been further established in a 2-year placebocontrolled trial that combined xenical with lifestyle intervention by physicans who specialize in treating obesity, and in a 1-year placebo-controlled study of patients with type 2 diabetes treated with oral sulfonylurea medications. The present study evaluated the efficacy of xenical online in producing and maintaining long-term weight loss, and in improving obesity-related risk factors in individuals who are obese and who received limited dietary and behavioral counseling in a primary care setting.